The discovery supports the theory that Alzheimer's disease is a metabolic brain disease similar to obesity and diabetes being peripheral metabolic diseases. Researchers suggest treatments for obesity that are under development could prove useful against Alzheimer's disease as well.
"We discovered that these fatty acids are produced by the brain -- that they build up slowly with normal aging -- but that the process is accelerated significantly in the presence of genes that predispose to Alzheimer's disease," said Karl Fernandes, a professor at the University of Montreal, in a press release. "In mice predisposed to the disease, we showed that these fatty acids accumulate very early on, at two months of age, which corresponds to the early twenties in humans. Therefore, we think that the build-up of fatty acids is not a consequence but rather a cause or accelerator of the disease."
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